The industrial production of a wound-healing cream containing fibroblast growth factors (FGF) and epidermal growth factors (EGF) on chitosan nanoparticles.
EGF & FGF in Wound Treatment
Cell Proliferation
Encourage rapid cell division and multiplication, speeding up the healing process.
Cell Migration
Promote migration of essential cells to the wound site for closure and healing.
Angiogenesis
FGF promotes new blood vessel growth, enhancing nutrient and oxygen delivery.
Collagen Production
Crucial for wound strength and integrity.
Wound Healing Process:
Strategies for Improved Performance
1. Hemostasis
Clot formation to stop bleeding (EGF and FGF not directly involved).
2. Inflammation
White blood cells clear debris and prevent infection (minor role for EGF and FGF).
3. Proliferation
Regeneration of new tissue (major role for EGF and FGF).
- EGF: Stimulates keratinocyte growth and migration.
- FGF: Stimulates fibroblasts, collagen production, and angiogenesis.
4. Remodeling
Maturation and rearrangement of collagen fibers for scar tissue formation and wound strengthening (FGF regulates fibroblast activity and collagen production).
Fibroblast Growth Factor (FGF)
Roles in Wound Healing
-
Angiogenesis:
Promotes new blood vessel formation, ensuring oxygen and nutrient delivery to the wound. -
Tissue Repair:
Stimulates fibroblast proliferation, aiding in connective tissue matrix generation and granulation tissue formation. -
Re-epithelialization:
Assists in keratinocyte migration, helping to close the wound and form a protective barrier.
Epidermal Growth Factor (EGF)
Roles in Wound Healing
-
Cell Proliferation:
Stimulates epidermal and dermal cell proliferation, replenishing cell loss from the wound. -
Cell Migration:
Promotes keratinocyte migration, aiding in wound closure and re-establishment of the epidermal barrier. -
Collagen Production:
Influences dermal fibroblasts and collagen production, crucial for skin structure.
